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Novasource^Ⓡ

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Novasource^® products are developed to offer nutrition for patients with disease specific needs.

Proven to increase lower gastrointestinal tolerance due to the unique partially hydrolysed guar gum fibre (PHGG)
Specific formulas available for a range of chronic illnesses such as kidney disease, diabetes and hyperglycaemia
Can deliver a range of products according patients’ particular nutritional status

The Novasource^® portfolio contains products for your patients changing needs.

Adapted carbohydrate blend
High quality protein
Adapted lipid blend
Specialised PHGG fibre blend

Specialised nutritional needs in one streamlined and easy to navigate product range, so you can deliver optimal nutritional care across a range of ailments.

Key features and benefits of the Novasource® range:

Many of the physiological effects of PHGG are due to its fermentation by colonic bacteria which leads to the production of Short Chain Fatty Acids, (SCFA) which exert various positive effects on colonic function.

PHGG fermentation increases production of beneficial SCFA, including butyrate, compared to other fibre sources such as: inulin, polydextrose and psyllium.³⁴

PHGG and Diarrhoea

SCFAs help regulate water and electrolyte absorption in the colon which may help normalize stool consistency.^30-31

Increased bacterial mass from fermentation increases fecal bulk, which also contributes to regularity of bowel movements.³⁰

PHGG and Microbiome

Butyrate is considered the most important SCFA for colonic health, and is the preferred fuel for colonic epithelial cells, which metabolize 60-70% of the SCFA produced.³²

PHGG supports intestinal flora balance by promoting growth of beneficial bacterial strains, lactobacilli and bifidobacteria.³³

PHGG and Blood Glucose

PHGG has been shown to significantly reduce plasma glucose compared to a fiber-free formula in ICU patients.³⁵

PHGG significantly reduced plasma and capillary glucose levels, and insulin requirements, in patients with diabetes or stress induced hyperglycemia.³⁶

*Novasource renal does not contain PHGG.

**FOS, fructo-oligosaccharide.

aen-novasource-left - Key Fact Block

ESPEN recommends the use of PHGG to prevent enteral nutrition induced diarrhoea in post-surgical and in critically ill-patients³⁹

ESPEN 2018 Guideline on clinical nutrition and hydration in geriatrics

“...fiber containing products for EN have been shown to contribute to normal bowel function and are, thus, generally recommended.
...enterally nourished patients should not be deprived of the well-known beneficial metabolic effects of dietary fiber.”

Daily amounts of 25g are considered adequate for normal laxation for adults of all ages and can be considered.⁴⁵

aen-novasource-right - Key Fact Block

PHGG is guideline-recommended for diarrhoea prevention⁴⁰

PHGG is a 100% soluble dietary fibre, a highly viscous fibre extracted from the guar plant⁴¹

PHGG is a water-soluble fibre with strong clinical support in the management of diarrhoea^40-44

Its special composition as native guar gum means that it ferments more slowly than short chain fibres (such as inulin and FOS**)

This may influence tolerance as rapidly fermenting fibres are associated with increased gas

References

Velázquez M., et al., Effect of Oligosaccharides and Fibre Substitutes on Short-chain Fatty Acid Production by Human Faecal Microflora. Anaerobe 2000 vol: 6 (2) pp: 87-92;
Alam N., et al., Partially hydrolyzed guar gum-supplemented oral rehydration solution in the treatment of acute diarrhoea in children. Journal of pediatric gastroenterology and nutrition 2000 vol: 31 (5) pp: 503-507;
Topping D. & Clifton P., Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides. Physiological Reviews 2001 vol: 81 (3) pp: 1031-1064;
Yoon S., et al., Physiological Functions of Partially Hydrolyzed Guar Gum. J. Clin. Biochem. Nutr. 2006 vol: 39 pp: 134-144;
Mesejo, A., et al., Comparison of a high-protein disease-specific enteral formula with a high-protein enteral formula in hyperglycemic critically ill patients. Clinical Nutrition, 2003. 22(3): p. 295-305;
Takahashi H., et al., Effect of partially hydrolyzed guar gum on fecal output in human volunteers. Nutrition Research 1993 vol: 13 (6) pp: 649-657;
Wells C. et al., Effect of fiber supplementation of liquid diet on cecal bacteria and bacterial translocation in mice. Nutrition 1992 vol: 8 (4) pp: 266-71;
Takahashi H., et al., Influence of partially hydrolyzed guar gum on constipation in women. Journal of nutritional science and vitaminology 1994 vol: 40 (3) pp: 251-9;
Lochs H, et al. Introductory to the ESPEN Guidelines on Enteral Nutrition: Terminology, definitions and general topics. Clin Nutr 2006;25(2):180-186;
Meier R, Gassull M. Consensus recommendations on the effects and benefits of fibre in clinical practice. Clin Nutr Suppl 2004;1(2):73-80;
Meier R, Gassull M. Consensus recommendations on the effects and benefits of fibre in clinical practice. Clin Nutr Suppl 2004;1(2):73-80.
Lampe JW, et al. Gastrointestinal effects of modified guar gum and soy polysaccharide as part of an enteral formula diet. J Parenter Enteral Nutr 1992;16:538-544.
Rushdi RA et al. Control of diarrhoea by fibre-enriched diet in ICU patients on enteral nutrition: a prospective randomized controlled trial. Clin Nutr 2004;23:1344-1352.
Spapen H, et al. Soluble fibre reduces the incidence of diarrhoea in septic patients receiving total enteral nutrition: a prospective, double-blind, randomized, and controlled trial. Clin Nutr 2001; 20(4):301-305.
HomAnn et al. Reduction in diarrhoea incidence by soluble fibre in patients receiving total or supplemental enteral nutrition. J Parenter Enteral Nutr 1994;18:485-490.
HomAnn et al. Reduction in diarrhoea incidence by soluble fibre in patients receiving total or supplemental enteral nutrition. J Parenter Enteral Nutr 1994;18:485-490.

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