In a poster presentation titled, Clinical Effect of L-methylfolate in Patients Stratified by Baseline Obesity and Inflammation : a Randomized Clinical Trial of Patients with Major Depression, on October 1st at 2:00pm, Dr. Charles Raison, Associate Professor, Department of Psychiatry, University of Arizona School of Medicine, will discuss the findings of a multi-center, double-blind, placebo-controlled trial that identified correlations between L-methylfolate and antidepressant response in patients presenting with certain conditions, such as inflammation and obesity.
The study focused on 75 inadequate responders to SSRIs who were enrolled in a 60-day, multi-center, double-blind, placebo-controlled trial. Patients were given 15 mg/day of L-methylfolate for 60 days, placebo for 30 days followed by L-methylfolate 15 mg/day for 30 days, or placebo for 60 days. Results reported in the American Journal of Psychiatry revealed that inadequate responders (all-comers) given adjunctive L-methylfolate had significantly greater response and reduction in depressive symptoms than adjunctive placebo (SSRI monotherapy). In an exploratory analysis, a subgroup of patients with a baseline BMI of 30 or greater and hsCRP above the median responded even more robustly to adjunctive L-methylfolate than did all-comers. It was concluded that the presence of obesity and inflammation in individuals with depression may predict greater response to SSRI therapy augmented with L-methylfolate.
“This data is teaching us more about how biomarkers might be used to advance treatment strategies in depression,” said Dr. Raison. “This information is helping clinicians understand how to better select therapeutic options based on a patient’s underlying biological conditions. As we continue to explore these findings, future developments will no doubt continue to deliver advancements in the treatment of depression.”
Conference attendees will also have the opportunity to attend a Continuing Medical Education (CME) Symposium session titled, The Emerging Role of L-methylfolate in Depression: When, Where, and Why? Focus on Obesity, Inflammation, and Genetic Factors.
The CME, taking place September 30th at 12:00pm, aims to help clinicians explore genetic, metabolic and inflammatory markers that may assist in the selection of treatment options in Major Depressive Disorder.
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