Functional gastrointestinal symptoms such as regurgitation and vomiting, constipation, crying and colic are considered non-IgE mediated reactions. Atopic eczema is often not recognized as a possible consequence of ingestion of cow's milk protein.

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WHAT IS CoMiSS ® ?
We believe breast milk is the best food for infants. When in consultation with their healthcare professional, mothers and families find that optimal breastfeeding is not possible due to their infant’s medical condition, formulas for special medical purposes play a vital role in providing essential nutrients to infants. We have a global commitment to market breast-milk substitutes responsibly.
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CoMiSS® quantifies the number and severity of symptoms.
Suspicion of 'cow’s milk-related symptoms' based on the presence of a combination of the following symptoms:
Frequent regurgitation, vomiting, diarrhea, constipation (with/without perianal rash), blood in stool.
Runny nose, (otitis media), chronic cough, wheezing (unrelated to infection).
Atopic dermatitis, angioedema, urticaria unrelated to acute infections, drug intake manifestations.
Persistent distress or colic (≥ 3 hours per day wailing/irritable) at least 3 days/week over a period of > 3 weeks.
Up to 60% of affected infants have digestive symptoms.
Up to 30% of affected infants have respiratory symptoms.
Up to 70% of affected infants have skin-related symptoms.
Inconsolable crying is very common in infants with CMPA, while anaphylaxis is very rare.
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