ADVANCING THE MANAGEMENT OF SEVERE COW’S MILK PROTEIN ALLERGY
- Amino acid-based, hypoallergenic formula (AAF) for effective first-line relief from severe symptoms of cow’s milk protein allergy (CMPA) and/or multiple food allergies and/or malabsorptive conditions*1-6
- Contains 2’FL and LNnT†, to nurture infants’ developing immune systems7-11
- Designed to support gastrointestinal tolerance and to facilitate absorption in the most challenging conditions12-19
- Supports normal growth and development20,21
- Preferred taste over other AAF, which may increase long-term acceptance22
- Nutritionally complete. Suitable as a sole source of nutrition from birth or supplementary feeding from 6 months of age
Effectively relieves symptoms, supports gut recovery and healthy growth
Infants with CMPA and/or multiple food allergies may face an immediate challenge from skin, gastrointestinal and/or respiratory symptoms, while those with severe symptoms may also experience anaphylaxis, failure to thrive and/or complex gastrointestinal manifestations.4-6,23 Alfamino® HMO is proven to be hypoallergenic, provides effective symptom relief1-3 and supports normal growth.20,21
(e.g. eczema, urticaria…)
(e.g. vomiting, colic, diarrhoea…)
(e.g. inconsolable crying, failure to thrive, anaphylaxis…)
Alfamino® HMO’s is also designed to facilitate fat and calcium absorption and supports gut recovery.12-19 This is due to it’s unique composition which is lactose-free and low in osmolality. It also contains 24% medium-chain triglycerides (of total fat) and structured lipids.
CMPA is an immune-mediated disease. It is associated with gut microbiota dysbiosis, which impacts immune system maturation and leaves infants at an increased risk of infections and future allergies.25-33 Alfamino® HMO is the only amino acid-based formula to contain 2’-fucosyllactose (2’FL) and lacto-N-neotetraose (LNnT), which are structurally identical to two significant human milk oligosaccharides (HMO).+7-11
HMO support the growth of beneficial bacteria in the gut
HMO strengthen the gut barrier by promoting intestinal cell maturation
HMO eliminate pathogens through a decoy effect
HMO guide the maturation of the immune system, leading to a more balanced Th1/Th2 response
REDUCING INFECTIONS AND MEDICATION USE
Infants fed formula with 2’FL and LNnT† had fewer upper and lower respiratory tract infections6-8
Infants fed formula with 2’FL and LNnT† had lower antibiotic and antipyretic use6-8
Formula-fed and complementary feeding
Unsettled, persistent crying, vomiting & severe diarrhoea and faltering growth
Suspected multiple food allergies including CMPA
WHAT WOULD BE YOUR MOST IMPORTANT GOAL FOR SOPHIA?
- SYMPTOM RELIEF
- SUPPORT GROWTH
- SUPPORT IMMUNE HEALTH
For infants with multiple food allergies, including CMPA, who are complementary feeding but cannot be breastfed, symptom relief can be achieved by:
- A complementary diet with the elimination of the foods suspected of causing an allergic reaction4,5
- A proven amino acid-based formula, such as Alfamino® HMO, which has been shown to be safe and effective for infants with CMPA:1-3
CMPA and food allergies in general may impair growth as some symptoms may affect nutritional intake and/or the absorption of nutrients.4,5 Alfamino® HMO is nutritionally tailored for infants with severe symptoms of CMPA and other food allergies, and has been proven to support healthy growth and development:20,21
The development of the immune system of infants with CMPA is affected by gut microbiota dysbiosis and increased gut permeability.24-26,34
Alfamino® HMO is the only amino acid-based formula with 2’FL and LNnT to support the development of the immune system and reduce the risk of infections and associated medication use:9-11
Mean trial duration: 12 months
|INFANTS WITH CMPA6,7
Mean trial duration: 8.8 months
|LOWER RESPIRATORY TRACT INFECTIONS ||-55%*||-34%‡|
|FREQUENCY OF UPPER RESPIRATORY TRACT INFECTIONS||-42%*|
*p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.05 at 4 months only; ‡ p = N.S.
FREQUENTLY ASKED QUESTIONS
Our range of immune-nurturing formulas for cow’s milk protein allergy
Our range of nutritional solutions are tailor-made for infants and young children with cow’s milk protein allergy and other food allergies/intolerances. The complete range has been designed to help manage cow’s milk protein allergy earlier, with the right product from the beginning.Althéra® HMOAlthéra HMO is the first choice for infants and young children with CMPAAlfare® HMOAlfare HMO is the first choice for infants and young children with severe CMPA and/or multiple food intoleranceAlfamino Junior® HMOAlfamino® Junior HMO is the first choice for infant and young children with severe CMPA and/or multiple food allergies above 1 year of age
†Structurally identical Human Milk Oligosaccharides are not sourced from human milk.
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Nowak-Wegrzyn A, et al. Confirmed Hypoallergenicity of a Novel Whey-Based Extensively Hydrolyzed Infant Formula Containing Two Human Milk Oligosaccharides. Nutrients 2019;11(7):E1447.
Cekola P, et al. Clinical use and safety of an amino acid-based infant formula in a real world setting. Abstract presented at NASPGHAN. Chicago, IL, USA, October 2019.
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Nestlé Health Science, data on file. CINNAMON study.
Vandenplas Y, et al. Growth, tolerance and safety of an extensively hydrolysed formula containing two human milk oligosaccharides in infants with cow’s milk protein allergy. Abstract presented at PAAM. Florence, Italy, October 19, 2019.
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American Academy of Pediatrics, Committee on Nutrition. Pediatrics 1976;57:278-285.
Nestlé Health Science, data on file. Alfamino® product composition.
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Vandenplas Y, et al. Growth in infants with cow’s milk protein allergy fed an amino acid-based formula. Abstract N-O-013 presented at ESPGHAN, 2019. J Pediatr Gastroenterol Nutr 2019;68(Suppl 1).
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Mothers should be encouraged to continue breastfeeding even when their infants have cow’s milk protein allergy. This usually requires qualified dietary counseling to completely exclude all sources of cow’s milk protein from the mothers’ diet. If a decision to use a special formula intended for infants is taken, it is important to give instructions on correct preparation methods, emphasizing that unboiled water, unsterilized bottles or incorrect dilution can all lead to illness. Formula for special medical purposes intended for infants must be used under medical supervision.