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The brain of patients who have Mild Cognitive Impairment (MCI) lacks energy because there is less glucose available to use than normal, and therefore the brain is less efficient.


Glucose, a simple sugar, is the main source of energy source for the brain.

It has been estimated that the brain uses about 20% of the total amount of glucose in the body. However, people with Mild Cognitive Impairment (MCI) , glucose becomes less or unavailable as a source of energy and therefore the brain needs a substitute source of energy.


A substitute source of energy for the brain are ketones. Ketones are substances that are made when the body breaks down fat in the liver for energy. The normal amount of ketones available in the body can only cover 3% of the total energy consumption by the brain. So, it is necessary to find an external source to compensate the brain’s demand for energy.


A kind of fats called Medium Chain Triglycerides (MCT) are a major source of ketones and can supply energy to the brain. These help make up for the reduced use of glucose that happens in people with MCI.


Extra MCTs, provided through specific clinically proven oral nutritional supplement, can balance out the brain’s lack of fuel.

This extra fuel has a unique effect on memory and cognition function in MCI.


See the video about how ketones increase the energy in the brain.

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References


1. Mergenthaler P, et al. Trends Neurosci 2013;36:587–597
2. Cunnane SC, et al. Front Mol Neurosci 2016;9:53
3. Nugent S, et al. OCL 2016;23:D110
4. Camberos-Luna L, Massieu L. Neurochem Int 2020;133:104614